A Comparative Study on Anti-diabetic Effects of Aqueous Trigonella foenum graecum, Hibiscus cannabinus Linn, and Cicer arietinum extracts on Alloxan Induced Diabetic Male Albino Rats

Abstract

Objective: To compare anti-diabetic effect between the different aqueous extracts of green leafy plants locally available in North Karnataka region of India on alloxan induced diabetic male albino rats. Materials and Methods: The preparation of aqueous extracts, preliminary phytochemical analysis and toxicity screening test of 3 aqueous extracts was done by using standard protocol. To study anti-diabetic activity experimental rats were divided into five groups viz. Group I (Control), Group II (Diabetic, Alloxan monohydrate, 15mg/100g bwt, i.p.), Group III (Diabetic with Trigonella foenum graecum), Group IV (Diabetic with Hibiscus cannabinus Linn) and Group V (Diabetic with Cicer arietinum). All above extracts were supplemented with same dose i.e. 12.5mg/100g bwt, orally. The blood glucose levels were evaluated in all the above experimental groups after acute (OGTT) and sub chronic (2 weeks) supplementation. Results: Our results depicts statistically significant decreased blood glucose level in Group III rats after both acute and sub chronic supplementation whereas in Group IV rats only after sub chronic supplementation when compared with Group II rats. But, Group V rats not showed any significant change in both acute as well as sub chronic exposure when compared with Group II rats. Conclusion: Trigonella foenum graecum and Hibiscus cannabinus Linn. leaves may be used as a dietary supplement in diabetic patients.