Simultaneous sensing of mesalazine and folic acid at poly (murexide) modified glassy carbon electrode surface

Abstract

The electro analytical determination of Mesalazine (MSZ) and Folic acid (FA) were done using a murexide-based sensor developed on a glassy carbon electrode. Electro oxidations for MSZ and FA were investigated in buffer (PBS) of pH 7.4 using cyclic voltammetry. This work was carried out to study the effect of change in the con centration of MSZ, scan rate, and pH of the electrochemical behaviour of MSZ on poly-murexide modified glassy carbon electrode [poly(MX) MGCE] surface. The limit of detection of MSZ was found to be 9.1 × 10− 5 M in the linear concentration range of 2.5 × 10− 4 M to 12.5 × 10− 4 M. The modified electrode has also shown good sensitivity for detection of FA and simultaneous detection of MSZ and FA. The two distinct individual peaks at the corresponding peak potentials of MSZ and FA were obtained. The poly (MX) MGCE electrode showed a stable, reproducible, and sensitive result for MSZ and FA.