Microfluidics temperature compensation and tracking for drug injection based on mechanically pulsating heat exchanger

Abstract

To assure correct patient care and lower pharmaceutical mistakes that might cause serious harm or death, this research intro- duces a microfluidic heating flowmeter for tracking injectable pumping based on a mechanically pulsating heat exchanger. It is impossible to use the usual gravimetric approach for flow-rate measurement in clinics because it necessitates extensive preparations and laboratory equipment. Consequently, there is a huge need for a standard technique substitute that can be used for distant, frequent, small-scale infusion-pump surveillance. Here, to give precise measurements, the research presents a downsized heated flowmeter made of a silicon platform, a platinum heating layer atop a silicon dioxide thin membrane, and polymer microchannels. A microfluidics temperature compensation and tracking method is suggested in this research. Based on this architecture, the research put forth a heat transmission concept in which the researchers looked at the regional correlations among the macro-scale temperature detector and the microscale liquids. The accuracy of temperature manage- ment for microscale reagents was demonstrated using a series of temperature-sensitive nucleic acid multiplication experi- ments. The efficacy of the heat transport model is further confirmed by comparisons of mathematical and empirical data. The isothermal multiplication polymerase chain reaction temperature-related minor fluctuations in fluorescence intensity could be identified with the aid of the compensatory method that was given. If the amplifying temperature differs by 1 °C, the likelihood density plots of fluorescence intensity are significantly different from one another. This technique is useful for micro–macro-interaction monitoring generally and extends beyond microfluidic purposes.